Health
Research

“Nothing in life is to be feared, only to be understood”

MARIE CURIE

Ongoing projects

BIT and MEDECA

Cancer research | An accurate multi-analyte blood test leading to an earlier detection of occult cancer.

BIT and MEDECA

An accurate multi-analyte blood test leading to an earlier detection of occult cancer.

Sweden

Cancer research

2017

<p><strong>Cancer</strong> remains a leading cause of death, due in great part to delayed diagnosis. Cancer detection is, however, difficult in patients without organ-specific symptoms. This interdisciplinary long-term project investigates blood biomarkers indicative of occult cancer, with a focus on host response (NETs) and tumor-derived markers (liquid biopsies).</p> <p><strong>Conducting</strong> two large clinical studies (including patients at risk of occult cancer), the researchers are developing a simple blood test selecting high-risk patients for a rapid and targeted cancer diagnostic work-up. This could result in shortened diagnostic delay, prompt cancer treatment, and ultimately reduce cancer-related morbidity and mortality.</p>

<div class="carousel-item active"><img width="945" height="630" src="https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-2.png" class="d-block w-100" alt="" srcset="https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-2.png 945w, https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-2-300×200.png 300w, https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-2-768×512.png 768w" sizes="(max-width: 945px) 100vw, 945px" /><p class="carousel-jcajf-caption">Photo: Magnus Laupa</p></div><div class="carousel-item"><img width="559" height="379" src="https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-1.png" class="d-block w-100" alt="" srcset="https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-1.png 559w, https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-1-300×203.png 300w" sizes="(max-width: 559px) 100vw, 559px" /><p class="carousel-jcajf-caption">Photo: Magnus Laupa</p></div>

COMMUNITY

COVID-19 research | A follow-up study investigating how the immune response develops over time after SARS-CoV-2 infection.

COMMUNITY

A follow-up study investigating how the immune response develops over time after SARS-CoV-2 infection.

Sweden

COVID-19 research

2020

<p><strong>The COMMUNITY study</strong> aims to investigate how the immune system develops over time after SARS-CoV-2 infection. Blood samples were collected from 2149 hospital workers and 118 COVID-19 patients at Danderyd Hospital during the first phase of the study in April/May 2020. Serology analyses showed that all patients and a high portion of hospital workers (19.1%) had developed IgG antibodies against SARS-CoV-2.</p> <p><strong>Follow-up blood samples</strong> will now be collected after 4 and 10 months, to investigate the duration and efficacy of antibody responses as well as contributing parts of the immune response involving T-cells. The COMMUNITY study constitutes an excellent study group in which to explore immune response over time, as it contains longitudinal data from a large group of individuals with varying degrees of SARS-CoV-2 exposure and infection.</p> <p> </p>

<div class="carousel-item active"><img width="945" height="630" src="https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-2.png" class="d-block w-100" alt="" srcset="https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-2.png 945w, https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-2-300×200.png 300w, https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-2-768×512.png 768w" sizes="(max-width: 945px) 100vw, 945px" /><p class="carousel-jcajf-caption">Photo: Magnus Laupa</p></div><div class="carousel-item"><img width="653" height="437" src="https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-3.png" class="d-block w-100" alt="" srcset="https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-3.png 653w, https://jonasandchristinaafjochnickfoundation.com/wp-content/uploads/2020/07/Charlotte-3-300×201.png 300w" sizes="(max-width: 653px) 100vw, 653px" /><p class="carousel-jcajf-caption">Photo: Magnus Laupa</p></div>

FINGER study – dietary intervention

Diet and brain health | Part of the wider FINGER study into preventive measures involving brain health, the dietary intervention and cognition project focuses on the role of diet in this area.

FINGER study – dietary intervention

Part of the wider FINGER study into preventive measures involving brain health, the dietary intervention and cognition project focuses on the role of diet in this area.

Sweden

Diet and brain health

2018

<p><strong>Since it is often hard to raise funds</strong> for the more general topic of Alzheimer’s, the FBHI (FINGERS Brain Health Institute) decided to raise funds individually for specific projects, of which the ‘dietary intervention and cognition project’ is one.</p> <p><strong>The project</strong> hopes to clarify exactly how diet affects brain aging, to what extent it can slow down or cure dementia, and whether coconut oil can strengthen these positive effects.</p>

Per-Olof Berggren at the Karolinska Institute

Diabetes Research | Professor Per-Olof Berggren at the Karolinska Institute has developed a unique in vivo imaging approach to enable identification of novel drugable targets for diabetes treatment.

Per-Olof Berggren at the Karolinska Institute

Professor Per-Olof Berggren at the Karolinska Institute has developed a unique in vivo imaging approach to enable identification of novel drugable targets for diabetes treatment.

Sweden

Diabetes Research

2012

<p><strong>Over 450 million people have diabetes worldwide</strong> – and it’s growing rapidly. Treatment of type 2 diabetes and its severe complications primarily focuses on identifying novel, more specific drugable targets and, based on these, designing new drugs that can be applied for more effective pharmacological regimens.</p> <p><strong>In type 1 diabetes</strong> the major problem is to improve the success rate of islet transplantation. Professor Berggren and his group aims firstly to understand regulation of islet cell function and survival in the living organism and secondly the extent to which experimental work in rodents reflects the human islet.</p> <p><strong>They use the eye’s anterior chamber</strong> as a novel and superior transplantation site, with the cornea as a natural body window visualizing human islet cell biology in vivo, non-invasively, longitudinally at single cell resolution.</p>

Systems-immunology analysis in patients with severe COVID-19

COVID-19 research | A collaborative project with SciLifeLab/Karolinska Institute using genetic/immune system markers to determine why healthy individuals in rare instances develop severe COVID-19

Systems-immunology analysis in patients with severe COVID-19

A collaborative project with SciLifeLab/Karolinska Institute using genetic/immune system markers to determine why healthy individuals in rare instances develop severe COVID-19

Sweden

COVID-19 research

2020

<p><strong>Whilst it’s now understood</strong> that those over 70 or with underlying health conditions are firmly in the ‘at risk’ group for COVID-19, it’s less clear why some young, otherwise healthy individuals contract the virus and develop severe disease. The Karolinska Institute has promoted this project as of paramount importance in gaining an understanding as to whether there are specific biomarkers that will help identify at risk individuals on a cellular level, helping to reduce unnecessary fatalities by improving their care – particularly important for front-line healthcare professionals who have been considered high risk.</p> <p><strong>The purpose of this study</strong> is to better understand the immunological processes and mechanisms involved in the development of a cytokine storm (when the immune system is running amok) that kills patients with severe COVID19.</p>

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“Nothing in life is to be feared, only to be understood”

Ongoing projects

BIT and MEDECA

COMMUNITY

FINGER study – dietary intervention

Per-Olof Berggren at the Karolinska Institute

Systems-immunology analysis in patients with severe COVID-19

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